2-AMINO-2-NORBORNANECARBOXYLIC ACID

Name	2-AMINO-2-NORBORNANECARBOXYLIC ACID
Synonyms	BCH B-Bch 2-Aminonorbornane-2-carboxylic acid 2-AMINO-2-NORBORNANECARBOXYLIC ACID 2-Amino-2-carboxy-bicyclo-2,2,1-heptane 2-AMINOBICYCLO[2.2.1]HEPTANE-2-CARBOXYLIC ACID Bicyclo(2.2.1)heptane-2-carboxylic acid, 2-amino-
CAS	20448-79-7

Molecular Formula	C8H13NO2
Molar Mass	155.19
Density	1.256±0.06 g/cm3(Predicted)
Melting Point	>300°C(lit.)
Boling Point	295.5±23.0 °C(Predicted)
Solubility	Aqueous Acid (Slightly)
Appearance	Solid
Color	White
pKa	2.58±0.20(Predicted)
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature

WGK Germany

biological activity	BCH (2-aminocicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) it is a selective, competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells.
Target	Value
Cell Line:	KYSE30 and KYSE150 esophageal cancer cells KYSE30 and KYSE150 cells KYSE30 and KYSE150 cells
Concentration:	1 mM, 3 mM, 5 mM, 10 mM, 20 mM, 30 mM, 40 mM, 50 mM, or 100 mM 30 mM 30 mM
Incubation Time:	3 days 24 and 48 hours 0 hour, 0.5 hour, 1 hour, 3 hours, 6 hours, 24 hours
Result:	Cell proliferation was suppressed in a dose-dependent manner. Cell cycle arrest. Phosphorylation of 4E-BP1 and p70S6K was decreased. The amount of mTOR, 4E-BP1, and p70S6K proteins was slightly decreased. Significantly delayed tumor growth and decreased glucose metabolism.
Animal Model:	Male BALB/c nude mice (5-week-old) with KYSE150 cells
Dosage:	200 mg/kg
Administration:	Intravenous injection; daily; for 14 days
uses	inhibitors of amino acid transmembrane transport.